Abstract
In 2023, tuberculosis (TB) reached its highest incidence with 8.2 million new cases reported by the World Health Organization (WHO). The virulence of Mycobacterium tuberculosis (MTB) is strongly governed by protein-protein interactions (PPIs) that regulate essential processes such as cell wall biosynthesis, immune evasion, and persistence. This study aims to map and analyze the mechanisms of key PPIs in MTB using a scoping review approach. Data was retrieved from PubChem and related literature with the keyword ``PPIs Network TB''. Our findings highlight crucial PPI-driven mechanisms, including the role of DprE1/DprE2 in arabinogalactan synthesis, VapB4/VapC4 in stress response and self-toxicity, ESX-1 and Type VII Secretion System (T7SS) in virulence factor delivery, and the DosRST system in latent infection. Additionally, host-response proteins such as IL-6 and MMP-9 are identified as potential diagnostic biomarkers. By revealing these molecular interaction pathways, this review provides a roadmap for developing targeted anti-TB drugs and precision diagnostics tailored to MTB strain diversity.
Recommended Citation
Suryanto, Rajwa Dwifauza; Rumawan, Maritsa Widati Aqila; and Wicaksono, Imam Adi
(2026)
"Exploring Protein-Protein Interactions: A Promising Avenue for Biomarker and Anti-TB Drug Development,"
Pharmacology and Clinical Pharmacy Research: Vol. 11:
Iss.
1, Article 5.
DOI: 10.15416/pcpr.v11i1.65976
Available at:
https://journal.unpad.ac.id/pcpr/vol11/iss1/5
Page
35
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