Abstract
Neem leaves (Azadirahcta indica A. Juss) and shallots (Allium cepa L) contain flavonoids that are effective as an antioxidant, antibacterial, and anti-inflammatory. The aim of this study was to determine the effective concentration and the duration of treatment of the anti-inflammatory activity of the gel containing a combination of neem leaf extract and shallot extract. These substances have a similar effect, and it is believed that these combinations may effective as an anti-inflammatory at small doses to reduce the side effects. The animals were randomly divided into 6 groups with 5 rats per group. The rats were wound-induced by incising its back (length 1.5 cm, depth 0.7 mm) and were observed for 8 days. Parameters measured were wound’s closure, color, and healing process. Statistical analysis showed that the most effective concentration as an anti-inflammatory was formula 1 (neem leaf extract 3.125%: shallots extract 4%) with the fastest healing time was 5 days. Thus, this formula is one of the effective treatment options for healing wounds.Keywords: neem leaves, shallots, anti-inflammatory, combination, gel
Recommended Citation
Nurmala, Sara; Moerfiah, Moerfiah; and Purnama, Restu T.
(2020)
"Anti-inflammatory Activity of the Gel Containing a Combination of Neem Leaf Extract and Shallot Extract,"
Pharmacology and Clinical Pharmacy Research: Vol. 5:
Iss.
1, Article 6.
DOI: 10.15416/pcpr.v5i1.26133
Available at:
https://journal.unpad.ac.id/pcpr/vol5/iss1/6
Page
33
