RESOLUTION OF A RACEMIC ISOLEUCINE MIXTURE BY USING METHYL L-MANDELATE

Abstract

A methyl ester of L-mandelic acid was found to be an effective resolving agent for resolution of commercial DL-isoleucine. The resolution was based on Steglich esterification between methyl L-mandelate and Boc-DL-isoleucine. The two resolved isomers were easily separated by using a conventional flash-column chromatography, giving quantitatively good yields. Unfortunately, the methyl L-mandelate was found to be ineffective to resolve four stereoisomers of Fmoc- isoleucine.

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Volume

4

Issue

cna/vol4/iss3

Authors

Rani Maharani, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas PadjadjaranFollow
Ace Tatang Hidayat
Dadan Sumiarsa
Achmad Zainuddin
Ika Wiani Hidayat

Recommended Citation

Maharani, Rani; Hidayat, Ace Tatang; Sumiarsa, Dadan; Zainuddin, Achmad; and Hidayat, Ika Wiani (2016) "RESOLUTION OF A RACEMIC ISOLEUCINE MIXTURE BY USING METHYL L-MANDELATE," Chimica et Natura Acta: Vol. 4: Iss. 3, Article 9.
DOI: https://doi.org/10.24198/cna.v4.n3.10991
Available at: https://journal.unpad.ac.id/cna/vol4/iss3/9